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Note: Not all descendants are listed.
Mro Andrea Hofer of Germany, married 1598 Valletta to Grazia Caterina da Ponti, (illegitimate daughter of Caterina da Ponti), with issue.
1. Luca Heffner., married 1633 to Marchesa Caterina Malaspina, with issue.
1.1. Gregorio Heffner., married (1) 1675 to Caterina Sayd., married (2) 1684 to Anna del Fiore., with issue.
1.1.1. (Second Marriage) Dr Niccolo Heffner JUD., married 1729 Valletta to Anna Maria Galea, with issue.
1.1.1.1. Chco. Gaetano Heffner., married (1) 1752 Senglea to Maria Bugeja., married (2) 1776 Valletta Anne dei Conti Fournier., with issue.
1.1.1.1.1. (First Marriage) Niccolo Heffner., married (1) 1779 Domenica Palmier., married (2) 1808 to Elizabetta Coen.
1.1.2. Filippa Heffner, married 1740 Valletta to Dr Gio Maria Spiteri JUD.
1.1.3. Paolica Heffner, Nun, (Donation 1710 Notary Gio Domenico Pace).
1.2. Vittoria Heffner, married 1666 at Valletta to Antonio Casanova.
1.3. Agata Heffner., married 1654 (1) at Valletta to Giacchi Camilleri., married (2) 1662 to Mro Cesare Bezzina.
1.3.1. (First marriage) Bernarda Camilleri, married 1679 Matrice Gozo to Pietro Bugeja.
1.4. Bellica Heffner., married 1678 at Valletta to Antonio Orlando.
1.5. Camilla Heffner., married (1) 1664 to Michele Zammit., married (2) 1673 to Nicolao Curviseri.
1.6. Maria Heffner., married 1662 to Mco Albino Bezzina de Biasi.
2. Marcello Heffner, married 1639 Valletta to Marchesa Angelica Malaspina.